Police are appealing for witnesses to a fatal collision in Bulla yesterday afternoon.

Emergency services were called to a head-on collision between two cars on Sunbury Road about 3.20pm.

A 69-year-old male driver and a 68-year-old female passenger, both from Baynton, travelling in an SUV, died at the scene.

The driver of a Holder sedan, a 22-year-old Melton West man, was taken to hospital with non-life threatening injuries. He remains in hospital.

Sunbury Road was closed between Melbourne-Lancefield and Bulla-Diggers Rest roads for several hours and reopened just after 11pm last night.

Investigations are ongoing.

Anyone who witnessed the collision or has dashcam footage is asked to contact Crime Stoppers on 1800 333 000 or make a confidential report at www.crimestoppers.vic.gov.au