A man has died following a single vehicle crash in Melton West last night (February 4).

A vehicle hit a tree on High Street near Bulmans Road just before 9.30pm.

One man died at the scene.

Paramedics treated three other people, including a man aged in his 20s with head, chest and leg injuries. He was flown by air ambulance to The Alfred in a serious condition.

A man aged in his teens had chest, shoulder and leg injuries and a teenage woman was treated with hand injuries.

Both were taken to Royal Melbourne Hospital in a stable condition.

The cause of the crash is being investigated.