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LATEST: At least one home was destroyed and frightened residents and workers fled as a fast-moving fire came close to Epping and Campbellfield.

The grassfire became an out of control blaze, burning more than 2000 hectares as it  headed south from Donnybrook.

SEE: Epping fire forced evacuations at Northern Hospital

More than 600 firefighters in 120 trucks came from across Victoria to battle the flames on a hot and gusty day. They were supported by 11 waterbombing aircraft.

The Northern Hospital evacuated a childcare centre on its grounds and shoppers at Epping Plaza were asked to stay indoors.

By midnight on Monday, exhausted CFA, MFB and DSE firefighters had contained the fire, but were expected to spend the night tamping out embers and assessing damage. The front was halted near the corner of Hume Freeway and Cooper Street, having progressed along both sides of the freeway. It had been headed for Thomastown.

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A relieved Country Fire Authority deputy chief officer Steve Warrington said:  ‘‘It was a very dangerous, fast moving fire that had potential to cause significant damage, had it not been for the coordinated efforts of the Victorian fire agencies.

“We know we saved a number of houses but we know there’s one lost, in the north-eastern sector.”

Property developer Robert Scanlon said he had been told by police that three factories in the Northpoint Enterprise Park in Cooper Street, Epping, were feared destroyed. Mr Scanlon had undertaken the major project with another developer, which he said represented years of work.

Residents in Epping and Campbellfield and surrounding suburbs spent the afternoon and evening on high alert.

The CFA issued an emergency warning meaning lives were at risk. They urged residents to activate their fire plans, to leave if it was safe and to monitor radio bulletins.

Igniting about 1pm on Monday near Donnybrook Road, Donnybrook, the fire spread through Wollert towards homes and factories in Epping and Campbellfield.

By 7.30pm firefighters feared the flames would enter suburbia. Part of Cooper Street, Epping, was closed and the Hume Freeway was shut from Sydney Road to the Metropolitan Ring Road.

The City of Whittlesea opened its emergency centre that was previously used for Black Saturday and other residents headed for Epping Plaza shopping centre.

Residents of Aurora Estate, Wollert, endured a frightening afternoon during which they could see flames from the windows of their houses and dense smoke rising above the vacant paddocks and houses.

The grassfire swept past the properties on the edge of the estate, in vacant land on its western edge. On Monday afternoon and evening as many as seven helicopters could be seen flying above the fire, with some of them bombing the blaze.

Father of three Raheel Muhammad, of Edenvale Boulevard, said he packed his car with documents and a change of clothes for his children, in preparation to leave if necessary.

“We could see the flames right there, we could see the flames from our windows,” he said.

“The flames were really high up,”he said. The fire was just a few hundred metres from his house.

“It was a frightening afternoon,” he said.

Local Steve watched the fire from a small hill on the edge of the estate in the late afternoon and early evening. He had rushed home from work to check on his family and house in Aurora Estate.

Steve said that he sent his three children and his girlfriend to a friend’s place, a safe distance away from the blaze on the edge of suburbia.

“It was huge, it was huge. Smoke everywhere, flames everywhere,” he said.

Smoke was reported across Melbourne including the CBD. Traffic in the Epping area ground to a standstill as cars containing people evacuating merged with commuters, and, later, sightseers.

The fast-moving grass fire had headed south into metropolitan Melbourne, fanned by gusty northerly winds.

By 6pm it was heading along Cooper Street, Epping, and threatening homes near Rex Road, Campbellfield, and Edgars Road, Epping.

Victoria’s Fire Services Commissioner Craig Lapsley said roads were jammed with cars. “Roads are gridlocked out in that area,” Mr Lapsley told ABC radio. “People are either trying to get out or get home.”