Five female teenagers have been charged following an alleged affray in West Footscray that seriously injured two people.

The alleged incident occurred on Barkly Street shortly before 11am on Tuesday morning.

Ambulance Victoria spokesman Paul Bentley said paramedics treated a 43-year-old woman and 59-year-old man at the scene for upper body injuries.

They were both taken to Footscray Hospital in a serious but stable condition.

Victoria Police sergeant Cameron Scott said the teenagers were arrested a short time later without incident.

They were charged with affray and assault-related charges in relation to the incident.

They have been bailed to appear before a children’s court at a later date.